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For centuries, horse chestnut seeds, leaves, bark, and flowers have been used for a variety of conditions and diseases.
Horse chestnut seed extract has been used to treat chronic venous insufficiency (a condition in which the veins in the legs do not efficiently return blood to the heart). This condition is associated with varicose veins, pain, ankle swelling, feelings of heaviness, itching, and nighttime leg cramping.
Aescin is the active ingredient of the horse chestnut seed extract, namly the most commonly used form. The standardized extracts of horse chestnut seed contain 16 to 20 percents aescin (escin). Topical preparations have also been used.
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